Cytokinesis failure 翻译

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August undefined, 2024

WebAlarmingly, cytokinesis failure could be a pathological process leading to the genesis of unstable aneuploid cells undergoing malignant transformation. For example, during …

Understanding Cytokinesis Failure SpringerLink

WebNational Center for Biotechnology Information WebNov 5, 2024 · Cytokinesis failure can increase chromosomal instability beyond a critical threshold that triggers tumor suppression. Thus, agents developed to block cytokinesis can stop proliferation of cancer cells. We previously demonstrated that the polo-like kinase 4 (PLK4) inhibitor, CFI-400945, triggers growth inhibition and apoptotic death in diffuse ... list of towns and cities in usa

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WebDec 12, 2016 · CIT-K depletion causes cytokinesis failure in multiple cell lines and activates the Hippo tumor-suppressor pathway in normal, but not cancer cells. It has … http://www.iciba.com/word?w=bypass Web爱词霸英语为广大英语学习爱好者提供金山词霸、在线词典、在线翻译、英语学习资料、英语歌曲、英语真题在线测试、汉语查词等服务,爱词霸英语在线查词和在线翻译频道致力于为您提供优质的在线查词及在线翻译服务 ... Saphenous vein graft occlusion is a main reason ... immobility respiratory complications

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Chromosome mis-segregation and cytokinesis …

WebFeb 7, 2024 · 3.2. Misaponin B Induced Cytokinesis Failure in A549 Cells. Cytokinesis was evaluated in Misaponin B-treated A549 cells. Briefly, A549 cells were treated with different concentrations (15, 30 μM) of Misaponin and stained with DAPI for immunofluorescence.As shown in Figures 2(a) and 2(b), a fraction of α-tubulin was … WebMar 27, 2024 · Time-lapse microscopy revealed that strong RNA interference (RNAi)-mediated silencing of KIF14 induced cytokinesis failure, causing several rounds of endoreduplication and resulting in multinucleated cells. Additionally, less efficacious KIF14-specific short interfering RNAs (siRNAs) induced multiple phenotypes, all of which … list of townships in indianaWebNov 28, 2024 · The most prominent and immediate consequence of cytokinesis failure is the formation of a tetraploid daughter cell with two centrosomes (Lacroix and Maddox, 2012). The tetraploid state is unstable and often develops into aneuploidy as a result of a continued cell cycle with more than two centrosomes, leading to the miss-segregation of … list of townships in illinois

"WebCytokinesis failure leads to both centrosome amplification and production of tetraploid cells, which may set the stage for the development of tumor cells. However, tetraploid … " - Cytokinesis failure 翻译

Cytokinesis failure 翻译

http://www.ichacha.net/cytokinesis.html WebAug 14, 2024 · during mitosis and the midbody during cytokinesis (Lee et al, 2008). Cytokinesis is a tightly controlled process during cell division requiring multicomponent subunits that are recruited to the midbody in a CEP55-dependent manner (Fabbro et al, 2005; Bastos & Barr, 2010; Mondal et al, 2012; Agromayor & Martin-Serrano, 2013).

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WebJun 18, 2010 · Cytokinesis. Cancer. Midbody. 1. Introduction. Cytokinesis is the physical separation of two daughter cells during cell division and is the final stage of the cell cycle [1]. After anaphase and chromosomal segregation, cells form a contractile ring which is a network of actin and myosin filaments, to drive the constriction of the plasma ... Webfailure (n.). 1640年代， failer ，意为“失败，缺陷”，也指“失败的行为”，源自盎格鲁-法语词汇 failer ，古法语 falir ，意为“缺乏；未成功”（参见fail（v.））。在盎格鲁-法语中，动词被用作名词；17世纪英语将其结尾改为与-ure中的单词相一致。指“被视为失败的事物或人”的含义始 …

WebApr 14, 2024 · 其中术后肝衰竭(post-hepatectomy liver failure，PHLF)正是肝癌手术治疗最致命的并发症。肝切除术作为肝癌的一线疗法，其5年生存率接近70%。大量患者由于肿瘤体积过大或存在多个肿瘤需要进行大范围肝切治疗。 WebDec 12, 2016 · Here, we investigated whether causing polyploidy by cytokinesis failure could represent a useful approach. We show that cytokinesis failure caused by depletion of Citron kinase (CIT-K) dramatically decreased cell proliferation in breast, cervical and colorectal cancer cells. CIT-K depletion activated the Hippo tumor suppressor pathway in …

WebJan 16, 2024 · Multiple rounds of cytokinesis failure lead to the creation of the multinucleated cardiomyocytes seen in tetralogy of Fallot. WebFeb 14, 2024 · Abstract. Mutations in citron (CIT), leading to loss or inactivation of the citron kinase protein (CITK), cause primary microcephaly in humans and rodents, associated with cytokinesis failure and apoptosis in neural progenitors. We show that CITK loss induces DNA damage accumulation and chromosomal instability in both mammals and Drosophila.

WebMar 18, 2005 · Fig. 1. ( A) Schematic diagram of a dividing cell. ( B) The core proteins for cytokinesis in animal cells, arranged by functional class. Core proteins are defined by …

Web节点无法启动、并显示"error：failure to build endpoint environment variables" 扩展/隐缩全局定位节点无法启动、并显示"error：failure to build endpoint environment variables" 最后更新; 另存为PDF Views: 2 ... list of towns and cities in vermontWebCytokinesis defects and cancer. Whole-genome and centrosome duplication as a consequence of cytokinesis failure can drive tumorigenesis in experimental model … immobility splintWebNational Center for Biotechnology Information immobility symptomsWebCytokinesis is a mechanical process during which a cell undergoes major mechanical deformation. Thus, an in-depth understanding of the effects of mechanical signals on cell mechanics and biochemistry is required. A diverse tool set is available to study cell mechanics during cytokinesis, allowing characterization of various mechanical parameters. list of town names in montanaWebMay 5, 2015 · We showed that up-regulation of SPG20 expression, brought about by trisomy 13 in DLD1+13 and AF+13 cells, is sufficient for the cytokinesis failure phenotype. Overall, our study shows that aneuploidy … immobility syndrome definitionWebMar 18, 2005 · The central spindle: a set of microtubule-based machines. Anaphase onset marks the beginning of cytokinesis. The proteolytic destruction of cyclins inactivates mitotic kinases and permits dephosphorylation and activation of several proteins that are critical for assembly of the central spindle, a set of antiparallel microtubules that become bundled … immobility syndrome symptomsWebApr 6, 2024 · 蓝屏：DRIVER_POWER_STATE_FAILURE (9f) 蓝屏原因似乎是从win11 21h2 更新到22h2导致出了问题： ... 我们使用翻译服务协助我们的用户。请原谅语法错误。你好，我是独立顾问 Meo 通过 dump 文件分析得出是 amdacpbus.sys 导致的异常。 immobilization by wayne w. dyer