Cytofectins

Author: sngp

August undefined, 2024

WebCationic lipids (cytofectins) have gained widespread acceptance as pharmaceutical polynucleotide delivery agents for both cultured cell and in vivo transfection, and the cytofectins DOTAP and... WebMay 24, 2024 · Cytotoxic drugs can kill cells or stop them from growing and dividing. Genotoxic drugs cause damage to the DNA inside the cells. Carcinogens damage DNA in cells. This causes mutations that can lead …

National Center for Biotechnology Information

WebSep 28, 2008 · Finally, the compounds have been introduced into man in a gene therapy clinical trial recently initiated by Nabel etal. Because there is now a rapidly growing list of compounds that act by a similar mechanism we are referring to this class of polynucleotide delivery reagents as the “Cytofectins”. WebJul 21, 2008 · A range of monocationic and dicationic dioxyalkylglycerol cytofectins have been synthesised possessing methylene and short n-ethylene glycol spacers. The monocationic compounds were found to be effective in transfections when formulated as lipopolyplexes with peptide and DNA components, in particular with shorter PEG head … cultural safety evaluation tool

www.iprdb.com

WebSep 17, 1996 · Amine containing compounds and their use in the generation of cytofectin:polynucleotide complexes for transfection of cells, formulations, counterions, and reaction conditions for maximizing the transfection include using cationic amine compounds that have the general structure: ##STR1## wherein R.sub.4 and R.sub.5 are a pair of … WebDec 21, 2001 · We report herein the design, synthesis, and transfection biology of a novel series of non-glycerol-based cationic lipids with lactic acid-derived head groups The … WebFeb 5, 1999 · The most promising advances in nonviral gene transfer have been in the production of synthetic cationic liposomes formulated with cationic lipids (cytofectins) able to transfect cells. Such... east lothian ladies golf

Novel cationic amphiphiles as delivery agents for antisense ...

WO1998014439A1 - Piperazine based cytofectins - Google Patents

Webionic lipids (cytofectins) have been used in many lipid-DNA formulations, and since the report of the cytofectin DOTMA2 which is often used with the neutral lipid dioleoyl L-α-phosphatidylethanolamine (DOPE) (Fig. 1), a range of related lipids have been described.1e,3 The aim in developing new cytofectins has been to optimise the delivery ... WebTo evaluate additional delivery methods for the gene, Genzyme has an exclusive research agreement for the use of Vical's cytofectins as non-viral delivery vectors for CFTR. Also under investigation are delivery systems for the nasal epithelium using liposomes or lipid-DNA complexes. east lothian landscapingWebFeb 1, 1996 · Cationic lipids (cytofectins) have gained widespread acceptance as pharmaceutical polynucleotide delivery agents for both cultured cell and in vivo transfection, and the cytofectins DOTAP and DC-Cholesterol are being tested in clinical human gene therapy trials. This study reports the effects of modifications in the hydrophobic domain … cultural roots band

"WebCompositions and methods of protecting aquatic invertebrates from disease is shown. In one embodiment, dsRNA or antisense RNA to a nucleic acid molecule of the disease-causing mic " - Cytofectins

Cytofectins

Cationic liposome-mediated DNA transfection in ... - Gene Therapy

WebOct 10, 2008 · Equimolar mixtures of the new cytofectins with DOPE, which has a strong tendency to adopt an inverted hexagonal structure (H 11 phase) and which has the … WebCationic lipids (cytofectins) have gained widespread acceptance as pharmaceutical polynucleotide delivery agents for both cultured cell and in vivo transfection, and the cytofectins DOTAP and DC ...

Did you know?

WebCytotoxin (CTX) is a basic polypeptide that belongs to the three-finger toxin family. It is one of the significant toxins constituting approximately 40–60% of the cobra venom (Gasanov … WebTypically, cytofectins are combined with a neutral zwitterionic lipid such as a phospholipid, because it has been found that the two amphiphilic lipid species in combination are able …

WebBoth single-stranded and double-stranded DNAs were active in the presence of cytofectins. Macrophage activation by the DNA-cytofectin complexes was reduced by chloroquine, … WebJun 28, 2015 · A large number of liposome-based non-viral gene and siRNA delivery systems include monovalent cholesteryl cytofectins with acyclic head groups in their formulations. Progress in their clinical...

WebMar 9, 2011 · Cytotoxins. Cytotoxins are the chemical weapons that Killer T-cells use to destroy infected cells. Viruses take over healthy cells and trick them into making many … WebSep 28, 2008 · Cationic amphiphiles (cytofectins) are widely used for the transfection of cultured cells, and may become useful for the development of genetic medicines. …

WebNov 1, 2005 · Novel N,N‘-diacyl-1,2-diaminopropyl-3-carbamoyl[bis-(2-dimethylaminoethane)] bivalent cationic lipids were synthesized and evaluated for in …

WebSummary DNA, depending on base sequence, can induce a wide range of immune responses. While bacterial DNA is stimulatory, mammalian DNA is inactive alone and can, moreover, inhibit the response to ... cultural safety definition workplaceWebFeb 15, 2002 · Anchor-dependent lipofection with non-glycerol based cytofectins containing single 2-hydroxyethyl head groups Detailed structure-activity investigations aimed at probing the anchor chain length dependency for glycerol-based lipofectins have been reported previously. cultural safety community servicesWebSep 28, 2008 · Download Citation Cationic Lipid/Polynucleotide Condensates for in Vitro and in Vivo Polynucleotide Delivery - the Cytofectins Abstract Cationic liposomes have … east lothian kitchen fittersWebThis invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this inventio east lothian licensing boardWebCefoxitin is an antibiotic used to treat a wide variety of bacterial infections. It may also be used before and during certain surgeries to help prevent infection. This medication is known as a ... east lothian ladies county golf associationWebHere, two homologous cationic cholesteryl cytofectins 3 beta[N-(N',N'-dimethylaminoethane)-carbamoyl] cholesterol (DC-Chol) and 3 beta[N-(N',N'-dimethylaminopropane)-carbamoyl] cholesterol (Chol-T) with 2 and 3 carbon spacer elements, respectively, have been formulated into liposomes with near equimolar … cultural safety checklistWebPromising advances in nonviral gene transfer have been made as a result of the production of cationic liposomes formulated with synthetic cationic lipids (cytofectins) that are able to transfect cells. However few cationic liposome systems have been examined for their ability to transfect CNS cells. east lothian library login