Clathrin heavy chain domain

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August undefined, 2024

http://cucurbitgenomics.org/feature/gene/CsaV3_6G001890 WebFeb 9, 2024 · This six protein complex is composed of three clathrin heavy chains and three smaller clathrin light chains (CLCs) that form a three-legged pinwheel (Supplementary Fig. 1a) 17.

Structure and Assembly of Clathrin Cages SpringerLink

WebAug 30, 2016 · Abstract The clathrin heavy chain N-terminal domain interacts with endocytic adapter proteins via clathrin binding motifs to assemble clathrin triskelia into cages. However, the precise mechanism of clathrin assembly is not yet known. Clathrin heavy chain is often described as a leg, with subdomains, representing the foot (the N-terminal domain), followed by the ankle, distal leg, knee, proximal leg, and trimerization domains. The N-terminal domain consists of a seven-bladed β-propeller structure. See more Clathrin is a protein that plays a major role in the formation of coated vesicles. Clathrin was first isolated and named by Barbara Pearse in 1976. It forms a triskelion shape composed of three clathrin heavy chains and three light … See more Clathrin performs critical roles in shaping rounded vesicles in the cytoplasm for intracellular trafficking. Clathrin-coated vesicles (CCV) … See more • Wakeham DE, Chen CY, Greene B, Hwang PK, Brodsky FM (October 2003). "Clathrin self-assembly involves coordinated weak interactions favorable for cellular regulation" See more The clathrin triskelion is composed of three clathrin heavy chains interacting at their C-termini, each ~190 kDa heavy chain has a ~25 kDa light chain tightly bound to it. The three heavy chains provide the structural backbone of the clathrin lattice, and … See more • Adaptin • AP180 • Cap formation • Cell migration • Dynamin • Endocytic cycle See more • MBInfo - Clathrin Mediated Endocytosis • Eukaryotic Linear Motif resource motif class LIG_Clathr_ClatBox_1 • Eukaryotic Linear Motif resource motif class LIG_Clathr_ClatBox_2 See more matthew lawrence in boy meets world

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WebApr 12, 2024 · The clathrin’s three-legged structure is formed by extending these heavy chains. The clathrin N-terminal domain, which is folded into a seven-bladed-propeller, is located near the distal end of the legs, while the C terminus is located near the apex [32,35]. Clathrin-mediated endocytosis regulates the amounts of key plasma membrane proteins ... Webclathrin heavy chain, CHC1 and CHC2 (Baisa et al., 2013). ... C1573A, along with the light chain C-terminal domain construct could achieve approximately 67% of wild-type clathrin assembly. WebDescription: Homo sapiens clathrin, heavy chain-like 1 (CLTCL1), transcript variant 1, mRNA. RefSeq Summary (NM_007098): This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge … hereditary dark circles under eyes

CDD Conserved Protein Domain Family: Clathrin - National …

Clathrin self-assembly is mediated by a tandemly …

WebMar 21, 2024 · CLHC1 (Clathrin Heavy Chain Linker Domain Containing 1) is a Protein Coding gene. Diseases ... WebSome of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. hereditary dead meatWebJan 23, 2007 · Clathrin heavy chain 1 Gene names Name Cltc Organism names Organism Mus musculus (Mouse) Taxonomic identifier 10090 NCBI Taxonomic lineage Eukaryota … hereditary – das vermächtnis

"WebDescription: Homo sapiens clathrin, heavy chain-like 1 (CLTCL1), transcript variant 1, mRNA. RefSeq Summary (NM_007098): This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge … " - Clathrin heavy chain domain

Clathrin heavy chain domain

WebJan 23, 2007 · Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the … WebClathrin is involved in vesicle formation in the trans-Golgi network (TGN)/endosomal system and during endocytosis. Clathrin recruitment to membranes is mediated by the clathrin heavy chain (HC) N-terminal domain (TD), which forms a seven-bladed!-propeller. TD binds membrane-associated adaptors, which have short peptide motifs, either the

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WebClathrin (Fig. 14.3, Coat proteins) is classified as an early coat protein ( Kaksonen et al., 2005; Lu et al., 2016 ). The basic subunit of clathrin is a triskelion, formed by a trimer of …

WebAug 11, 1998 · Clathrin triskelions form the lattice that organizes recruitment of proteins to coated pits and helps drive vesiculation of the lipid bilayer. We report the crystal structure at 2.6 A resolution of a 55 kDa N-terminal fragment from the 190 kDa clathrin heavy chain. WebClathrin heavy chain (Chc) is a constituent of clathrin-coated vesicles and serves important functions in endocytosis and intracellular membrane trafficking but appears to …

WebJan 13, 2012 · The N-terminal domain (TD) of the clathrin heavy chain is folded into a seven-bladed β-propeller that projects inward from the polyhedral outer clathrin coat. As … WebClathrin recruitment to membranes is mediated by the clathrin heavy chain (HC) N-terminal domain (TD), which forms a seven-bladed beta-propeller. TD binds membrane-associated adaptors, which have short peptide motifs, either the clathrin-box (CBM) and/or the W-box; however, the importance of the TD binding sites for these motifs has not been ...

WebClathrin heavy chain is composed of a terminal globular domain, a distal segment containing several areas sensitive to enzymatic cleavage, and a proximal segment …

WebMay 27, 1999 · The clathrin triskelion is a trimer of heavy-chain subunits (1,675 residues), each binding a single light-chain subunit, in the hub domain (residues 1,074–1,675). … matthew lawrence t bozWebDescription: Homo sapiens clathrin, heavy chain-like 1 (CLTCL1), transcript variant 1, mRNA. RefSeq Summary (NM_007098): This gene is a member of the clathrin heavy … hereditary debt• Murphy JE, Keen JH (1992). "Recognition sites for clathrin-associated proteins AP-2 and AP-3 on clathrin triskelia". J. Biol. Chem. 267 (15): 10850–5. doi:10.1016/S0021-9258(19)50096-5. PMID 1587861. • Corvera S (1990). "Insulin stimulates the assembly of cytosolic clathrin onto adipocyte plasma membranes". J. Biol. Chem. 265 (5): 2413–6. doi:10.1016/S0021-9258(19)39811-4. PMID 2154445. matthew lawrence girl meets worldWebThe amino-terminal domain of the clathrin heavy chain, which folds into a seven-bladed β-propeller, binds directly to several endocytic proteins via short sequences based on the consensus residues LLDLD. In addition to a single LLDLD-based, type I clathrin-binding sequence, both amphiphysin and epsin contain a second, distinct sequence that is also … matthew lawrence richland waWebApr 9, 2024 · Here we show in mammalian cells that the heavy chain of clathrin interacts with Atg16L1 and is involved in the formation of Atg16L1-positive early autophagosome precursors. hereditary deafnessWebMatch: XP_004138417.1 (PREDICTED: clathrin heavy chain 1 isoform X2 [Cucumis sativus]) HSP 1 Score: 3289.6 bits (8528), Expect = 0.0e+00 ... Clathrin heavy-chain terminal domain: coord: 5..343: IPR016024: Armadillo-type fold: SUPERFAMILY: SSF48371: ARM repeat: coord: 345..500: IPR016024: Armadillo-type fold: … matthew lawrence related to joey lawrenceWebProteomics studies revealed clathrin heavy chain (CLTC) as a major deficient protein on spindle–chromosome complexes in mouse SCNT embryos, and augmenting the expression of this protein by mRNA injection after SCNT led to improved chromosome congression at the first mitotic spindle in 40% of cloned embryos (Han et al., 2010 ). hereditary decapitate